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In humans, seizures have been reported after the overdose or ingestion of drug preparations

Dihydrotestosterone induces reactive oxygen species accumulation and mitochondrial fission leading to apoptosis of granulosa cells

Mueller, S.G., N

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Moderate CYP3A4 inhibitors (diltiazem, naproxen, amiodarone) produce smaller AUC increases (roughly 40% or less) and generally do not require dose adjustment, though clinical judgment applies in patients with multiple risk factors for bleeding [9]