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In clinical practice, a B1-B6-B12 injection may be considered when oral therapy is insufficient or not feasible, such as in malabsorption, severe deficiency, or when accelerated replenishment is desired under medical supervision

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MS analyses were performed using electrospray ionization (ESI) operating in the negative mode ionization using the following parameters: capillary potential of 1.0 kV, source temperature of 150 C and desolvation temperature of 600 C

2, along with the corresponding changes in the appearance of the skin with aging

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