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PMID: 41 YasudaMTSakakibaraHShimoiK

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Methods Participants Post-mortem brain tissue samples were obtained from 102 participants from the Rush Religious Orders Study and Memory and Aging projects, together regarded as ROSMAP 27

Proteostatic pathways are deregulated in middle-aged and aged Mda5 -/- HSCs To investigate the molecular mechanism underlying the youthful phenotype of Mda5 -/- HSCs, we performed bulk RNA-sequencing (RNA-seq) to compare young, middle-aged, and aged WT and Mda5 -/- HSC transcriptomes

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