Semaglutide Treatment of Antipsychotic-Treated Patients With Schizophrenia, Prediabetes, and Obesity: The HISTORI Randomized Clinical Trial
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28 days when refrigerated and handled aseptically
PMID 16397271
The gastrointestinal effects of tirzepatide persist throughout treatment, though they typically become less intense after the initial titration period
While certain trials were able to demonstrate superiority of a GLP-1 RA over placebo (LEADER, REWIND), the lack of head-to-head comparisons of these therapeutic options limits the ability to make definitive conclusions regarding the efficacy of one agent over another, especially considering the differences between the CVOTs regarding median follow-up, number of enrolled patients, statistical power, and proportion of patients with CVD