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The former mechanism is preferred because RS scavengers can be consumed during the reaction and may generate toxic radicals derived from the chelators (Halliwell and Gutteridge, 2015)

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[DOI] [PubMed] [Google Scholar] 65.Mei J., Sun J., Wu J., Zheng X

and (3) conducting patent searches in Orbit Intelligence/Questel, CAS SciFinder, Lens.Org, and the Espacenet (the European Patent Office) databases using (i) keyword based search strings

Both approaches represent significant advances beyond single-receptor agonists, addressing multiple aspects of metabolic dysfunction that contribute to obesity and type 2 diabetes