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These differences suggest tirzepatide's dual-receptor action produces more robust fat loss, though individual results vary significantly

In their respective obesity programmes the triple agonist reported larger mean reductions: retatrutide reached about 24.2% at 48 weeks in Phase 2 (NEJM 2023) and 28.3% at 80 weeks in Phase 3 TRIUMPH-1, while tirzepatide reported about 20.9% at 72 weeks in SURMOUNT-1

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Without UV photon energy to complete that conversion, you end up with receptor activation but no visible pigmentation