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PMID: 20439575

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While activating ARC AgRP/NPY neurons has been shown to be both aversive [136] and rewarding [144] depending on the duration of activation, the positive valence associated with inhibiting ARC AgRP/NPY neurons [136] lends itself well to targeting these neurons for obesity drug development

To contextualize the preclinical findings described below, it is important to note that different GLP-mediated mechanisms map to distinct clinical biomarkers and endpoints

[DOI] [PMC free article] [PubMed] [Google Scholar] 214.Perez-Lloret S., Barrantes F.J

Foods with a low glycemic index (55 or lower) aren't likely to cause significant increases in blood sugar levels