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Introduction One recent advance in the management of type 2 diabetes has been the development and clinical use of DPP-4 inhibitors and GLP-1 receptor agonists

Exenatide had 53% homology with GLP-1, had strong binding ability with GLP-1 receptor and was not easily degraded by DPP-4

The presence of primary cilia on islet cells is conserved across species (13) and has been shown to be critical for signaling of specific GPCRs to regulate islet insulin and glucagon secretion (14)

The outcome of these two gaps side effect management and lifestyle support is low real-world persistence

Screenings: blood pressure, cholesterol, diabetes, and cancer screenings (e.g., mammograms, colonoscopies)

When drugs such as Ozempic and Wegovy burst into the national spotlight, they transformed the conversation around obesity and weight loss seemingly overnight