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To assess the functional relevance of ASPL in ULK-mediated phosphorylation of VCP, we next performed live-cell imaging assays using G3BP-tdTomato knock-in U2OS cells stably expressing WT GFP-ASPL or D351A GFP-ASPL and either WT VCP or a phosphomimetic VCP mutant in which all three ULK-dependent phosphorylation sites (serine-13, serine-282, and threonine-761) were mutated to aspartates (3SD)

NAC may reduce heart disease risk by reducing oxidative damage to tissues in your heart ( Studies show that NAC may protect heart function and heart health in people with diabetes and those recovering from certain heart surgeries ( Summary NAC can reduce oxidative damage to your heart, which can, in turn, decrease your risk of heart disease

10.1016/S0140-6736(02)07952-7 99

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Elbracht, M