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Both IH and BF usually disappear upon cessation of doxycycline

Baseline liver function tests and regular monitoring at 3, 6, 12, and 24 weeks are required, with treatment discontinued if transaminases exceed three times the upper limit of normal

Sikiri et al., Life Sci., 1994

The lipolytic stimulus is characterized by the reduction of fat cells through inhibition of the adenosine or phosphodiesterase receptor, activation of the beta adrenergic receptor or inhibition of the alpha 2 receptor