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Several studies have indicated that bcl-2 protein expression can impaired apoptosis and is involved in the development of MDR (158), and MCF-7 human breast cancer cells with bcl-2 overexpression are resistant to adriamycin (159)

A stepwise NIT screening approach was implemented to recruit patients likely to have NASH and a high degree of liver fat and fibro-inflammation, reflecting F2 and F3 fibrosis without requiring a biopsy

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And this includes the immune system

Certain tasks, such as the Stroop Task and the Wisconsin Card Sorting Test, have demonstrated strong compatibility with neuroimaging studies, reinforcing their validity even when used outside imaging paradigms [513]