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doi: 10.1097/RHU.0000000000001949

Instead, they are typically blends of plant extracts, fibers, or other compounds that are promoted as a way to stimulate the bodys own GLP-1 secretion or attempt to mimic some of its metabolic effects

GLP-1s and thyroid cancer GLP-1s have been around for two decades, though its only in the last few years that newer drugs like semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro and Zepbound) have become effective front-line treatments for obesity

Historical Background and Scientific Context Advances in peptide synthesis during the late twentieth century enabled researchers to isolate and replicate biologically active peptide fragments from larger proteins

However, it is important to note that the reduction in CV deaths did not reach the prespecified threshold for statistical significance, meaning subsequent analyses should be viewed as hypothesis-generating rather than confirmatory