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Mechanism of Action Melanogenesis Stimulation: Activation of MC1R stimulates the synthesis and release of eumelanin (the protective, dark pigment, typically black/brown), as opposed to pheomelanin (the red/yellow pigment)

doi: 10.1186/s40478-020-01031-3 148 SchillingSChausseBDikmenHOAlmouhannaFHollnagelJOLewenAet al

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through indirect stimulation of dopamine and norepinephrine receptors

Within research settings, IGF-1 LR3 is often associated with increased muscle size and improved functional strength