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Practice guides suggest that these effects can be minimized by gradual dose escalation and effective prevention or mitigation during initiation of treatment, generally resulting in mild or moderate adverse events ( In the analysis of serious versus non-serious outcomes in cases, 1, 7, 11, 15, 13, and 3 AEs tended to be reported as serious AEs for albiglutide, exenatide, liraglutide, dulaglutide, semaglutide, and tirzepatide, respectively (Supplementary Table S3)