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If fatigue is severe, persistent, or paired with fainting, confusion, chest pain, or dehydration symptoms that dont settle, get medical advice promptly rather than pushing through

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5d) in the ACLT model

By integrating network pharmacology, MR analysis, and transcriptomic validation, we demonstrate that metformins multimodal actions, spanning metabolic regulation, neuroinflammation, and antiviral defense, may underlie its stronger neuroprotective effects

The benefits of GLP-1 therapy are context-dependent, with the clearest signals observed in individuals experiencing metabolic dysfunction

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