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Many patients find that fatigue diminishes over time as their body acclimates to the medication

Center for Drug Evaluation and Research (n.d.) Medications containing semaglutide , U.S

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Semaglutide is a peptide that is metabolised via proteolytic cleavage and does not rely on cytochrome P450 enzymes, which are responsible for metabolising many oral medications

Long-term tolerability and sustainability Some patients may find semaglutide more tolerable over the long term due to its fewer side effects and various long-term health benefits, or due to its simple titration schedule