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inhibiting NMDA receptors localized on GABA interneurons

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Dietary oxidised fat up regulates the expression of organic cation transporters in liver and small intestine and alters carnitine concentrations in liver, muscle and plasma of rats

Dysregulation of this pathway can bias TRP metabolism toward neurotoxic and pro-inflammatory metabolites, thereby amplifying excitotoxicity, oxidative stress, and immune-driven disturbances in glutamatergic and monoaminergic neurotransmission