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For example, PLB rescues GC pyroptosis by decreasing Wilms' tumor 1-associated protein-mediated m6A methylation [18], as well as inhibits proliferation and promotes apoptosis of GCs through inactivation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mTOR pathway [19]

*Correspondence: Carla Pelusi, [email protected] This article was submitted to Clinical Diabetes, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

18 , 27 , 28 , 29 , 30 , 31 The STEP trials showed both short and longerterm improvements in cardiometabolic risk factors in participants with overweight or obesity

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66.7% female) with newly diagnosed or relapsed GD attending the endocrinology outpatient clinics in a single institution were recruited between January 2019 and July 2020

381 According to current guidelines, initial antihypertensive drug therapy should consider a dual combination of an ACE inhibitor or angiotensin receptor blocker with a calcium channel blocker or diuretic (optimal single pill)