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I joined their program for weight loss, and it was very successful. Nerrisa L
Semaglutide works through several mechanisms: Appetite suppression: It acts on receptors in the brain to reduce hunger and increase feelings of fullness Delayed gastric emptying: It slows the rate at which food leaves the stomach, prolonging satiety Improved glycaemic control: It enhances insulin secretion and reduces glucagon release in a glucose-dependent manner These combined effects lead to reduced caloric intake and, consequently, weight loss
Hoit BD, Dalton ND, Erzurum SC, Laskowski D, Strohl KP, Beall CM
Because of the effects GLP-1 agonists have on digestion, the most common side effects for these medications are gastrointestinal problems, like (Tran, 2017): Nausea Vomiting Constipation Diarrhea Bloating Indigestion GLP-1 may worsen symptoms of severe gastroesophageal reflux (acid reflux or heartburn) and gastroparesisa condition where the stomach doesnt move food around as well and doesnt fully empty (Hinnen, 2017)
10.1073/pnas.0606714103 Proc
Packer M et al., SUMMIT, NEJM 2024 (NEJMoa2410027, PMID 39555826) : tirzepatide and HFpEF with obesity, HR 0,62 composite endpoint
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