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Reviewing previous IBD treatment response: If a biologic or advanced IBD treatment has not worked as expected, it may be appropriate to review treatment history, disease activity, drug levels, antibodies, timing of response and whether symptoms are due to inflammation or an overlapping condition

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(More information) In vivo studies indicate that allicin-derived organosulfur compounds may be poorly bioavailable, whereas water-soluble derivatives of -glutamyl-L-cysteine peptides have been detected in plasma, liver, and kidney following oral consumption

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Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)

There is no reason not to have them more regularly