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doi:10.1152/japplphysiol.00945.2010

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The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI

We retested these compounds in IMR90 ER:RAS cells, and in a melanoma cell line, SK-MEL-103, in which we induced senescence by treatment with the chemotherapeutic agent etoposide or the Aurora kinase inhibitor tozasertib (Supplementary Fig