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3, B and C, both delivery methods yielded the anticipated biologic activity

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SLC1A5 might not be an appropriate target for suppressing glutamine uptake by cancer cells because it is not the only plasma membrane glutamine transporter, and its function would therefore be compensated by other redundant glutamine transporters such as SLC38A1 and SLC38A2

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In contrast, the AWARD-11 trial for Trulicity showed modest weight loss as a secondary endpoint in type 2 diabetes patients: approximately 6.6 lbs with the 1.5mg dose, 8.4 lbs with 3mg, and 10.1 lbs (about 4.6 kg) with the highest 4.5mg dose at 36 weeks