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71%) liver tumors than did wild-type mice exposed to a peroxisomal proliferator (Wy-14,643), suggesting carcinogenic response is a possible consequence of structural differences in human and mouse PPAR-(Morimura et al

However, the putative liver toxicity of methotrexate should be evaluated in the context of advances in our knowledge of the pathogenesis and natural history of liver disease, especially non-alcoholic fatty liver disease (NAFLD)

Br Med J 2:478479 Rumack BH (1984) Acetaminophen overdose in young children

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Its treatment was reported to increase the levels of GSH and the activities of GPX and GST, along with a decrease in cardiac lipid peroxide production in a rat model of myocardial injury caused by diazinon (a pesticide) [180]