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They simply cannot reach the brain in therapeutic concentrations

The reuptake of GABA is mediated by GATs, with GAT-1 utilizing the electrochemical gradients of Na+ and Cl - to transport extracellular GABA back into presynaptic and postsynaptic neurons, thereby facilitating the termination of GABAergic signaling

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Millam, J

Pure IGF 1 has a woefully low half-life, meaning the amount of time it spends in the human body causing changes is very low