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Concentrations were then corrected for these with the following formula: where [Mcorr] is the corrected concentration, [M] is the water-referenced metabolite concentration from the LCmodel output, fCSF is CSF fraction in the voxel, fGM is GM fraction in the voxel, and fWM is GM fraction in the voxel

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In clinical studies, higher levels of circulating long- and medium-chain acylcarnitines showed mixed results in patients with Alzheimers disease [24, 25] whereas clinical trials of patients with Parkinsons disease have consistently shown that circulating levels of long-chain acylcarnitines are decreased [26,27,28]

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