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Aringer et al

Hyperpigmentation and Dark Spots in Pregnancy During pregnancy, its common for dark spots and uneven pigmentation to appear on your skin, often called melasma or mask of pregnancy. These spots typically show up on the forehead, upper lip, and cheeks

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In a medical context, immune balance means the immune system responds appropriately: strong enough to defend the body, but regulated enough to avoid unnecessary tissue damage from persistent inflammation