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Apart from increasing the binding affinity of GLP-1, compound 2 also acts as an agonist on its own, thereby being classified as an ago-allosteric modulator (ago-PAM) of GLP-1R 25,28

124,142 Investigations into mechanism of action-mediated pharmacokinetic DDIs are currently limited to those mediated by the slowing of gastric emptying, with examples summarized in other reviews

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doi: 10.1126/science.847460

You can repeat for up to 15 minutes after the injection

Scientists initially expected participants with the PAM variant to have lower levels of GLP-1 because the hormone might be less stable without proper amidation