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While NO is largely implicated in hemostatic mechanisms, in tail-amputation-models under heparin- and warfarin-administration, both the NO-synthase (NOS)-blocker, L-NAME (prothrombotic) and the NOS-substrate L-arginine (antithrombotic), were little investigated

Desmond, Thomas C

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Accordingly, the cancer-specific evidence discussed in the present review should be interpreted by distinguishing mechanistic findings from preclinical models and safety data derived from clinically approved regimens