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Studies have revealed that one effect of low estrogen concentrations in PMW is GM dysbiosis, which leads to elevated levels of osteoclastogenic cells (Th17 cells, CD4+ T cells) and the pro-osteoclastogenic cytokine TNF-

doi: 10.1080/02699052.2019.1587000 21 LaurindoLFBarbalhoSMGuiguerELda Silva Soares de SouzaMde SouzaGAFidalgoTMet al

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doi: 10.1002/jcb.29858 25 KwonJLeeSKimY-NLeeIH

Although thiamine deficiency is rare in developed countries, it can lead to severe neurological disorders, emphasizing the importance of adequate thiamine intake for optimal health and as treatment when administered promptly (, )