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Without adequate methyl donor availability, the liver accumulates triglycerides as fat dropletsthe hallmark of non-alcoholic fatty liver disease (NAFLD)

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Topical peptides are useful for certain applications (GHK-Cu copper peptide has reasonable evidence for topical activity), but for the major therapeutic peptides growth hormone secretagogues, BPC-157, Epithalon systemic delivery is required to produce the effects seen in the research literature

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1997;37:166-74 58 -De Simone ea.Acta Vitaminol Enzymol