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Peripheral afferent signals relayed via MTNs, such as those induced by periodontal disease or bacterial infection, can accelerate locus coeruleus neurodegeneration, implicating MTNs as conduits linking oral pathology to Alzheimers disease-related neurodegeneration (Pisani et al., 2023)

It's worth noting that metformin, commonly prescribed alongside GLP-1 receptor agonists, is associated with vitamin B12 deficiency, which can cause memory impairment and neurological symptoms

Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype

Role of vitamins in neurodegenerative diseases: a review

In research settings, dosing varies based on study design, route of administration, participant profile, and monitoring requirements

Mendoza N, Diaz-Ropero MP, Aragon M, et al