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Patients with uncontrolled hypothyroidism may experience worsening fatigue or other symptoms that could be confused with GLP-1 side effects

Research suggests yerba mate may increase GLP-1 production, potentially promoting insulin secretion and satiety

These changes impair nociceptive threshold regulation and neuronal resilience

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Many patients continue maintenance dosing indefinitely to sustain weight loss, while others cycle off under medical supervision once they've established new eating patterns