Fernndez IF, Blanco S, Lozano J, Lazo PA
At first glance, this may seem an appropriate and straightforward way to quantify the treatment effect, but there are several reasons why the placebo-adjusted effect sizes of a drug in RCTs do not necessarily indicate the effect sizes that are achieved in real-life patient management
10.1016/0006-2952(76)90344-0 179 RoseM
Patients commonly report: Dramatically reduced hunger and cravings Faster and more consistent fat loss Improved energy and metabolic performance Easier adherence to calorie-controlled diets By addressing both hormonal appetite signals and glucose regulation , Tirzepatide helps patients achieve sustainable weight loss , not temporary results
That same study reported on drug use and here again the U.S
You do not only care about where the top of the tree is