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This issue, however, was rekindled and became a subject of debate with the 1996 approval by the US FDA of mandatory folic acid fortification of staple food products for the prevention of neural tube defectaffected pregnancies (13)

This process enables more oxygen and nutrients to be delivered to skin cells, thus improving cellular metabolism and making the skin look healthier and brighter

Our study revealed negative regulation of LRP1-binding proteins (e.g., TIMP2, FN1, SERPINE2, MMP2, DCN, C1S, C1R, and CTSD) in chondrocytes exposed to H 2 O 2 , corroborating findings from LRP1 knockdown models [85], except for PSAP, which was downregulated in our study but upregulated in LRP1 knockdown models

Jin for critical reading of the manuscript and preparation of the figures

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Glutathione biosynthesis: -glutamylcysteine synthetase from rat kidney