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We did expect some degree of positive findings, but the extent to which these findings were positive in our study was a little bit surprising, Sheth told Healio

Lifelong high-dose supplementation with a combination of biotin and thiamin is generally the treatment for biotin-thiamin-responsive basal ganglia disease (116)

10.1016/j.freeradbiomed.2020.04.016 20 ArzanlouM

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While the investment may differ for each patient, the benefits of safe, professionally supervised treatment far outweigh the risks of cheaper, unregulated alternatives

As the majority of TP53 mutations are missense and located in the DNA binding domain, synergy experiments were performed with the SKM1 cell line, which harbors a homozygous hotspot mutation of TP53 (p