This difference in mechanism is what makes the combination potentially valuable
Habibalahi et al, 2022) and others (Huang et al, 2022
Conceptually, these pathways should be viewed not as isolated modules but as an integrated redox defense network, in which failure of one arm can be partially compensated by the others until a critical threshold of lipid peroxide accumulation is exceeded
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(2) We applied cryo-EM to demonstrate that, when incubated with liposomes, Arabidopsis MVB-localized, BAR domain-containing SNX proteins generate significantly shorter tubules than mouse SNX1 in vitro
This configuration enables monovalent engagement of a second target (e.g., an anti-CD3 scFv), two distinct targets, or further engineering opportunities such as split scFvs or protease-activated IL-2