glp 1 doses GLP-1 Dose Increase Guide: Titration for Semaglutide & Tirzepatide One size fails all? The

In the SURMOUNT-1 trial, people treated with tirzepatide lost up to 22.5% of their body weight over 72 weeks , making it even more effective than semaglutide (NEJM tirzepatide study)

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The proposed mechanism involves controlling glutamate release in the synaptic cleft, modulating NMDA receptor stimulation, affecting excitatory amino acid transporter (EAAT)-mediated reuptake, and maintaining the glutamate/glutamine cycle within astrocytes

doi: 10.1046/j.1523-1755.1998.00918.x

Common Side Effects Estradiol elevation: HCG stimulates testicular aromatase, potentially raising estradiol and requiring monitoring