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Many semaglutide medications like Ozempic and Rybelsus are still only approved for treating type-2 diabetes, but drug companies have rushed to create weight loss-specific versions to capitalize on the craze

Along with cell growth, IGF-1 also promotes cell survival and protects against cellular damage

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SGLT-2 inhibitors and GLP-1RA, should be the preferred treatment for patients with type 2 diabetes and cardiorenal diseases after metformin

including adult patients with either T1D or T2D treating with mecasermin rinfabate (12 mg/kg/day for 14 days) showed lowered exogenous insulin requirements while improving glycaemic control

However, macrophages in more advanced plaques also have reduced lysosome function and trapping of free and esterified cholesterol within their lysosomes contributes to the overall sterol accumulation in the lesion (156-158)