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The preclinical data demonstrates the mechanistic foundation, while existing human research on dihydroberberine's bioavailability and glucose metabolism effects provides additional validation

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Funding This work was supported by grants from the National Natural Science Foundation of China (NSFC Numbers 81672800, 81603009, 81673020, 81802632, and 82173830), Natural Science Foundation of Shaanxi (2020JQ-445), and the Key Research and Development Program of Shaanxi Province (2021SF-207, 2021SF-223, and 2022ZDLSF05-19)

doi: 10.1002/jnr.25342 30

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