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Absent fibrosis (f0) was compared to histological findings of fibrosis of any stage (f1f4)

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EVs also mediate indirect toxicity by transferring miRNAs (e.g., miR-29b and miR-7) from astrocytes to neurons, thereby suppressing neuroprotective factors and disrupting synaptic integrityeffects that are potentiated by morphine [152, 153]

Scientists are still exploring whether these biological actions are direct effects of the peptide or secondary effects of overall cellular signaling

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