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2 | MATERIALS AND METHODS 2.1 | Reagents Yohimbine, loperamide, red phenol, gum Arabic, 55-dithio- bis (2-nitrobenzoic acid) (DTNB), Trichloroacetic acid (TCA), Butylhydroxytoluene (BHT), methanol, charcoal meal, ether, Bovinserumalbumin(BSA),NaCl,Bovincatalase,Epinephrine, Chlohydric acid (Hcl), GSH, tris, tartrate, methyl cellulose, ethylenetetra-acetic (EDTA),sodiumhydroxide(NaOH), folin- ciocalteu,salicylicacid,coppersulfate(CuSO4),thio-barbituric acid (TBA), sodium carbonate (NaCO3), sodium bicarbonate (NaHCO3),andhydrogenperoxide(H2O2)werep urchasedfrom (Biomaghreb,Ariana,Tunisia)andwereISO9001cer tified

Diarrhea : Reported by around 8% of participants in clinical trials

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Research progress on aroma enhancement strategies for fruit wine

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Approximately 20.9% of patients on the 12 mg dose reported dysesthesia, a condition involving skin sensitivity, tingling, or tenderness to touch