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Methods Network-based identification of natural products Construction of the AD-related pathway-gene network In this study, we aimed to screen AD-related pathways from three perspectives: Most Studied Pathways (pathways with the most literature on AD), Gene-Associated Pathways (derived from AD-associated gene enrichment analysis), and Popular Pathways (pathways showing an increasing trend in the literature)
We followed up on two hits that exhibited the strongest GxE interactions, SLC25A19 and SLC25A32, which are transporters of two B family vitamin-derived cofactors, thiamine pyrophosphate (ThPP, or vitamin B 1 ) and folate species (vitamin B 9 ), respectively
Redox Biol, 2013
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