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PubMed Ho, E.N., Kwok, W.H., Lau, M.Y., Wong, A.S., Wan, T.S., Lam, K.K., Schiff, P.J., Morishima, M., & Wong, C.H

Animal studies show protection against stomach ulcers from NSAIDs, alcohol, stress, ischemia-reperfusion, and cysteamine

Fatigue and dizziness improve with rest

It inhibits NNMT, lowering 1-MNA formation while increasing availability of nicotinamide for NAD salvage and SAM for other methylation reactions

Although it is not approved for human use by any major regulatory body, interest in NNMT inhibition as a research target has driven study of 5-Amino-1MQ in metabolic models