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The tirzepatide exposure in pediatric patients was within the range observed in adult patients

The worldwide prevalence of gout, defined as deposition of monosodium urate crystals mostly in the peripheral joints, ranges from 0.1 to 10 %, and its incidence varies 0.3 to 6 per 1000 person-years [4]

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Although preclinical studies reveal GLP-1 receptor expression within reproductive tissues and possible direct mechanisms, current human data remain inconclusive