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In support of a role for the GPx-1 polymorphisms in breast cancer risk, a nested casecontrol study from Denmark found that Leu carriers ( i.e heterozygous, Leu/Pro, plus homozygous, Leu/Leu) had significantly increased risk of breast cancer compared to Pro/Pro homozygotes (301)

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140 mg/kg as the loading dose, and then 70 mg/kg every 4 h for 3 days 76,77

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