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Additionally, even if you dont have an MTHFR gene mutation, your toxic burden, which is an accumulation of toxins in your body, can affect the methylation process

Trends Pharmacol Sci (2021) 42:8595

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NAD+ Flux Regulation: Studies focus on its mechanism of blocking NNMT, which may otherwise drain methyl groups and Nicotinamide, theoretically boosting the available pool of NAD+

If you lose weight faster than this, it could be due to losing water weight or even muscle mass, which isn't healthy