The results indicate that low exposure levels (~100 ng g 1 ) in the hindbrain and peripheral tissues are probably meaningful and may contribute to the effects of mGIPR-Ab on body weight
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Given the role of vascular dysfunction with both myocardial dysfunction and impaired exercise capacity in HFpEF 54 , and the known expression of GLP-1 receptors in the vasculature, we hypothesized that the weight loss-independent actions of semaglutide in HFpEF might involve improved vascular function
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Interestingly, the mitochondrial morphology changes triggered by exendin-4 in Control RNAi-treated cells were accompanied by a significant reduction in ERMCS length, which appeared already reduced under vehicle conditions without further effect of exendin-4 following SPHKAP downregulation or in GLP-1R KO cells, with no apparent effect of SPHKAP-EGFP overexpression in INS-1 832/3 cells in this parameter (Fig
