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10.1007/s00018-011-0689-3 Cell Mol

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Furthermore, the limited DNA repair capacity in mitochondria makes it difficult for mtDNA to recover from oxidative damage

There are counteracted muscle wasting, significantly corrected deranged muscle proliferation as well as myogenesis, counteracted increase of the proinflammatory cytokines such as IL-6 and TNF-, looking at muscle metabolism relevant to cancer cachexia as well as the changes in the expression of FoxO3a, p-AKT, p-mTOR, and P-GSK-3 (Kang et al., 2018)