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Initial findings with liraglutide, using both in vitro and in vivo (animal models) GLP-1R assays, had shown it was challenging to achieve an optimal balance between a long plasma half-life and sufficiently high GLP-1R affinity in the presence of albumin (46)

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Physiol Behav 2006

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We considered studies that are ongoing or completed, published or unpublished, and trials that are randomized or nonrandomized for inclusion in this review

Some studies indicate that amylin induces greater satiety than GLP-1s do