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Although less exquisitely well-characterized mechanistically, retrograde NO is also involved in presynaptic plasticity in many brain regions, often serving to reduce excitatory Glu or increase inhibitory GABA release from afferent axons (Yang and Calakos, 2013)

Banerjee S

Brain Research

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The peptide demonstrates a capacity to counteract damage caused by neurotoxic agents (dopamine system disruptors and excitotoxic compounds) in animal studies